IoT in healthcare: A scientometric analysis

This paper reviews scientific articles and patents about Internet of Things (IoT) in healthcare. The aim is to explore both the domain of research and the one of practice simultaneously. We compare the annual growth, the country production, and the trend topics of publications and patents, by focusing on the most relevant themes concerning the IoT in the healthcare industry. The analysis started with the selection of the publications and patents for the period 2015–2020. Since this comparative analysis between scientometric data in healthcare is new, the findings of this study can represent the basis for future studies to determine novel research opportunities on IoT. The study provides scholars with a better understanding of IoT research in healthcare and simultaneously extends knowledge of entrepreneurship in this field. Practitioners may benefit from this review to understand new and underexplored opportunities

Earth stabilisation via carbonate precipitation by plant-derived urease for building applications

Raw (unfired) earth represents a sustainable and efficient alternative to traditional construction materials but its dissemination into building practice has been hindered by a relatively high vulnerability to water erosion. Enzyme induced carbonate precipitation (EICP) can improve the durability of earth materials without using traditional chemical binders such as cement and lime. EICP utilises the urease enzyme to catalyse the hydrolysis of urea, which produces carbonate ions that react with the calcium ions dissolved in the pore water, thus resulting in the precipitation of calcium carbonate. The calcium carbonate fills the soil voids and binds particles together, which reduces water permeability and increases material strength. The urease enzyme is a hexameric protein that is found in the tissues of many common plants. This work proposes a low-cost and simple stabilisation technology that makes use of crude urease enzyme extracted from soybeans. This technology is applied to the stabilisation of compacted earth, whose properties are then assessed via unconfined compression, moisture buffering and durability tests. The findings suggest a noticeable improvement of material strength and durability, though further investigation is necessary to increase the competitiveness of EICP stabilisation against standard techniques using cement and lime

A comparative study of the effects of particle grading and compaction effort on the strength and stiffness of earth building materials at different humidity levels

This paper presents an investigation of the mechanical properties of three different earth building materials manufactured by compacting two soils with distinct particle size distributions under two markedly different efforts. Multiple samples of each material have been equalised either inside a climatic chamber at different humidity levels or oven-dried, before being subjected to shearing inside a triaxial cell to measure the corresponding levels of strength and stiffness. Triaxial shearing has been performed under different levels of radial stress to investigate the effect of material confinement inside thick walls. Consistent with previous research, the study has indicated that strength and stiffness increase as ambient humidity reduces and degree of saturation decreases, though the actual variation of these properties strongly depends on the dry density and clay content of the material. Most importantly, particle grading has emerged as a key material parameter, whose impact on earth building has often been overlooked. Particle grading appears to influence strength and stiffness even more than compaction effort, dry density and average particle size, which are usually quoted as the most important variables for the design of earth building materials

verification of a parkinson s disease protein signature in t lymphocytes by multiple reaction monitoring

Diagnosis of Parkinson's disease, the second most common neurodegenerative disease, is based on the appearance of motor symptoms. A panel of protein biomarkers in the T-lymphocyte proteome was previously proposed as a Parkinson's disease signature. Here, we designed an LC–MS based method to quantitatively evaluate this protein signature by multiple reaction monitoring (MRM) in T-lymphocytes and peripheral blood mononuclear cells from a new cohort of nine patients with Parkinson's disease and nine unaffected subjects. Patients were classified using the discriminant function obtained from two-dimensional electrophoresis and protein amounts measured by MRM, thus assigning seven controls out of nine as true negatives and nine patients out of nine as true positives. A good discriminant power was obtained by selecting a subset of peptides from the protein signature, with an area under the receiver operating characteristic curve of 0.877. A similar result is achieved by evaluating all peptides of a selected pane..

An evidence map and synthesis review with meta-analysis on the risk of incisional hernia in colorectal surgery with standard closure.

Purpose To assess the incidence of incisional hernia (IH) across various type of incisions in colorectal surgery (CS) creating a map of evidence to define research trends, gaps and areas of future interest. Methods Systematic review of PubMed and Scopus from 2010 onwards. Studies included both open (OS) and laparoscopic (LS). The primary outcome was incidence of IH 12 months after index procedure, secondary outcomes were the study features and their influence on reported proportion of IH. Random effects models were used to calculate pooled proportions. Meta-regression models were performed to explore heterogeneity. Results Ninetyone studies were included reporting 6473 IH. The pooled proportions of IH for OS were 0.35 (95% CI 0.27–0.44) I2 0% in midline laparotomies and 0.02 (95% CI 0.00–0.07), I2 52% for off-midline. In case of LS the pooled proportion of IH for midline extraction sites were 0.10 (95% CI 0.07–0.16), I2 58% and 0.04 (95% CI 0.03–0.06), I2 86% in case of off-midline. In Port-site IH was 0.02 (95% CI 0.01–0.04), I2 82%, and for single incision surgery (SILS) of 0.06—95% CI 0.02–0.15, I2 81%. In case of stoma reversal sites was 0.20 (95% CI 0.16–0.24). Conclusion Midline laparotomies and stoma reversal sites are at high risk for IH and should be considered in research of preventive strategies of closure. After laparoscopic approach IH happens mainly by extraction sites incisions specially midline and also represent an important area of analysis.pre-print3102 K

Transition from Secondary school CLIL to EMI at University: Initial evidence from research in Italy

Through vocabulary tests, interviews with students and recordings of classes/lectures, we measured students' English vocabulary knowledge against the vocabulary in the teachers' talk, the nature of classroom interaction in the two settings and the students' approaches to their learning in general and their in-class listening strategies in particular. In this way we aimed to identify the challenges students faced in English-medium education in the secondary and tertiary educational phases

Preventing incisional ventral hernias: important for patients but ignored by surgical specialities? A critical review.

Purpose Incisional ventral hernias (IHs) are a common complication across all surgical specialities requiring access to the abdomen, pelvis, and retroperitoneum. This public health issue continues to be widely ignored, resulting in appreciable morbidity and expenses. In this critical review, the issue is explored by an interdisciplinary group. Methods A group of European surgeons encompassing representatives from abdominal wall, vascular, urological, gynecological, colorectal and hepato-pancreatico-biliary surgery have reviewed the occurrence of His in these disciplines. Results Incisional hernias are a major public health issue with appreciable morbidity and cost implications. General surgeons are commonly called upon to repair IHs following an initial operation by others. Measures that may collectively reduce the frequency of IH across specialities include better planning and preparation (e.g. a fit patient, no time pressure, an experienced operator). A minimally invasive technique should be employed where appropriate. Our main recommendations in midline incisions include using the ‘small bites’ suture technique with a ≥ 4:1 suture-to-wound length, and adding prophylactic mesh augmentation in patients more likely to suffer herniation. For off-midline incisions, more research of this problem is essential. Conclusion Meticulous closure of the incision is significant for every patient. Raising awareness of the His is necessary in all surgical disciplines that work withing the abdomen or retroperitoneum. Across all specialties, surgeons should aim for a < 10% IH rate.pre-print146 K

CD56, HLA-DR, and CD45 recognize a subtype of childhood AML harboring CBFA2T3-GLIS2 fusion transcript

The presence of CBFA2T3‐GLIS2 fusion gene has been identified in childhood Acute Myeloid Leukemia (AML). In view of the genomic studies indicating a distinct gene expression profile, we evaluated the role of immunophenotyping in characterizing a rare subtype of AML‐CBFA2T3‐GLIS2 rearranged. Immunophenotypic data were obtained by studying a cohort of 20 pediatric CBFA2T3‐GLIS2‐AML and 77 AML patients not carrying the fusion transcript. Enrolled cases were included in the Associazione Italiana di Ematologia Oncologia Pediatrica (AIEOP) AML trials and immunophenotypes were compared using different statistical approaches. By multiple computational procedures, we identified two main core antigens responsible for the identification of the CBFA2T3‐GLIS2‐AML. CD56 showed the highest performance in single marker evaluation (AUC = 0.89) and granted the most accurate prediction when used in combination with HLA‐DR (AUC = 0.97) displaying a 93% sensitivity and 99% specificity. We also observed a weak‐to‐negative CD45 expression, being exceptional in AML. We here provide evidence that the combination of HLA‐DR negativity and intense bright CD56 expression detects a rare and aggressive pediatric AML genetic lesion improving the diagnosis performance

Defining the characteristics of certified hernia centers in Italy: The Italian society of hernia and abdominal wall surgery workgroup consensus on systematic reviews of the best available evidences

Background: The terms “Hernia Center” (HC) and Hernia Surgeon” (HS) have gained more and more popularity in recent years. Nevertheless, there is lack of protocols and methods for certification of their activities and results. The Italian Society of Hernia and Abdominal Wall Surgery proposes a method for different levels of certification. Methods: The national board created a commission, with the task to define principles and structure of an accreditation program. The discussion of each topic was preceded by a Systematic Review, according to PRISMA Guidelines and Methodology. In case of lack or inadequate data from literature, the parameter was fixed trough a Commission discussion. Results: The Commission defined a certification process including: “FLC - First level Certification”: restricted to single surgeon, it is given under request and proof of a formal completion of the learning curve process for the basic procedures and an adequate year volume of operations. “Second level certification”: Referral Center for Abdominal Wall Surgery. It is a public or private structure run by at least two already certified and confirmed FLC surgeons. “Third level certification”: High Specialization Center for Abdominal Wall Surgery. It is a public or private structure, already confirmed as Referral Centers, run by at least three surgeons (two certified and confirmed with FLC and one research fellow in abdominal wall surgery). Both levels of certification have to meet the Surgical Requirements and facilities criteria fixed by the Commission. Conclusion: The creation of different types of Hernia Centers is directed to create two different entities offering the same surgical quality with separate mission: the Referral Center being more dedicated to clinical and surgical activity and High Specialization Centers being more directed to scientific tasks